Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr 14;10(1):1754538.
doi: 10.1080/20008686.2020.1754538. eCollection 2020.

Evaluation of a COVID-19 IgM and IgG Rapid Test; An Efficient Tool for Assessment of Past Exposure to SARS-CoV-2

Affiliations
Free PMC article

Evaluation of a COVID-19 IgM and IgG Rapid Test; An Efficient Tool for Assessment of Past Exposure to SARS-CoV-2

Tove Hoffman et al. Infect Ecol Epidemiol. .
Free PMC article

Abstract

COVID-19 is the most rapidly growing pandemic in modern time, and the need for serological testing is most urgent. Although the diagnostics of acute patients by RT-PCR is both efficient and specific, we are also crucially in need of serological tools for investigating antibody responses and assessing individual and potential herd immunity. We evaluated a commercially available test developed for rapid (within 15 minutes) detection of SARS-CoV-2-specific IgM and IgG by 29 PCR-confirmed COVID-19 cases and 124 negative controls. The results revealed a sensitivity of 69% and 93.1% for IgM and IgG, respectively, based solely on PCR-positivity due to the absence of a serological gold standard. The assay specificities were shown to be 100% for IgM and 99.2% for IgG. This indicates that the test is suitable for assessing previous virus exposure, although negative results may be unreliable during the first weeks after infection. More detailed studies on antibody responses during and post infection are urgently needed.

Keywords: COVID-19; IgG; IgM; diagnostics; rapid test; sars-CoV-2.

Figures

Figure 1.
Figure 1.
Number of PCR-positive cases positive or negative for IgM or IgG based on number of days after onset of COVID-19 symptoms.

Similar articles

See all similar articles

References

    1. Guarner J. Three emerging coronaviruses in two decadesthe story of SARS, MERS, and Now COVID-19. Am J Clin Pathol. 2020. March 9;153(4):420–5. - PMC - PubMed
    1. De Wit E, Van Doremalen N, Falzarano D, et al. SARS and MERS: recent insights into emerging coronaviruses [Internet]. Nature Reviews Microbiology Nature Publishing Group, London, UK; August 1 2016;523–534. Available from: www.nature.com/nrmicro - PMC - PubMed
    1. Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res. 2013;100:286–295. [Elsevier]. - PMC - PubMed
    1. Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. J Am Med Assoc. 2020;323(11):1061. .
    1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020. February 15;395(10223):497–506. - PMC - PubMed

LinkOut - more resources

Feedback