Cp*Co(III)-Catalyzed Ketone-Directed ortho-C-H Activation for the Synthesis of Indene Derivatives

Dattatraya H Dethe; Nagabhushana C B; Arsheed Ahmad Bhat

doi:10.1021/acs.joc.0c00727

CpCo(III)-Catalyzed Ketone-Directed ortho*-C-H Activation for the Synthesis of Indene Derivatives

J Org Chem. 2020 Jun 5;85(11):7565-7575. doi: 10.1021/acs.joc.0c00727. Epub 2020 May 13.

Authors

Dattatraya H Dethe¹, Nagabhushana C B¹, Arsheed Ahmad Bhat¹

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.

PMID: 32364736
DOI: 10.1021/acs.joc.0c00727

Abstract

A weakly coordinating, carbonyl-assisted C-H activation of aromatic systems with α,β-unsaturated ketone and subsequent aldol condensation has been developed using a Cp*Co(CO)I₂ catalyst. The developed method is the first example of indene synthesis by cobalt-catalyzed C-H activation. In addition, the reaction requires mild reaction conditions and easily accessible starting materials, and it shows excellent functional group compatibility.