Neonatal Abstinence Syndrome In The United States, 2004-16

Health Aff (Millwood). 2020 May;39(5):764-767. doi: 10.1377/hlthaff.2019.00814.


After increasing for nearly two decades, rates of neonatal abstinence syndrome have recently leveled off, reaching a plateau as early as 2014. These findings may represent successful efforts to prevent and treat opioid use before and during pregnancy.

Keywords: Access and use; Children’s health; Comorbidity; Drug use; Health conditions; Health policy; Neonatal abstinence syndrome; Opioid use disorder; Pharmaceuticals; Pregnant women; Withdrawal; costs and spending.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Analgesics, Opioid / therapeutic use
  • Female
  • Humans
  • Infant, Newborn
  • Neonatal Abstinence Syndrome* / diagnosis
  • Neonatal Abstinence Syndrome* / epidemiology
  • Neonatal Abstinence Syndrome* / therapy
  • Opioid-Related Disorders* / drug therapy
  • Opioid-Related Disorders* / epidemiology
  • Pregnancy
  • Pregnancy Complications* / epidemiology
  • United States


  • Analgesics, Opioid