Efficacy and safety of dupilumab in atopic dermatitis in elderly patients: a retrospective study

Clin Exp Dermatol. 2020 Oct;45(7):888-890. doi: 10.1111/ced.14260. Epub 2020 May 24.

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease with high prevalence in both children (15-30%) and adults (2-10%), but limited data are available for older people. Elderly patients form a challenging group, as multiple comorbidities, associated polypharmacy and failures with previous treatments are common. We performed a retrospective observational study on elderly (≥ 65 years) patients treated with dupilumab, monoclonal antibody to the shared alpha subunit of the interleukin-4 and -13 receptor approved for the treatment of moderate-to-severe AD in adults.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal, Humanized / administration & dosage
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Comorbidity
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / immunology
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Polypharmacy
  • Prevalence
  • Retrospective Studies
  • Safety
  • Severity of Illness Index
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal, Humanized
  • dupilumab