A human monoclonal antibody blocking SARS-CoV-2 infection

Nat Commun. 2020 May 4;11(1):2251. doi: 10.1038/s41467-020-16256-y.

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Neutralizing / immunology*
  • Antibodies, Neutralizing / pharmacology
  • Antibodies, Viral / immunology*
  • Antibodies, Viral / pharmacology
  • Antibody Affinity / immunology
  • Betacoronavirus / chemistry
  • Betacoronavirus / drug effects
  • Betacoronavirus / immunology*
  • COVID-19
  • Chlorocebus aethiops
  • Conserved Sequence
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / prevention & control*
  • Coronavirus Infections / virology
  • Cross Reactions / immunology
  • Epitopes, B-Lymphocyte / chemistry
  • Epitopes, B-Lymphocyte / immunology
  • Humans
  • In Vitro Techniques
  • Inhibitory Concentration 50
  • Models, Molecular
  • Pandemics / prevention & control*
  • Peptidyl-Dipeptidase A / chemistry
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / prevention & control*
  • Pneumonia, Viral / virology
  • Protein Binding / drug effects
  • Protein Domains / immunology
  • Receptors, Virus / chemistry
  • Receptors, Virus / metabolism
  • SARS Virus / chemistry
  • SARS Virus / drug effects
  • SARS Virus / immunology
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / immunology
  • Vero Cells

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Epitopes, B-Lymphocyte
  • Receptors, Virus
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2