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Review
. 2020 May 4.
doi: 10.1002/cbic.202000250. Online ahead of print.

Trends and Innovations in Biosensors for COVID-19 Mass Testing

Affiliations
Review

Trends and Innovations in Biosensors for COVID-19 Mass Testing

Ibon Santiago. Chembiochem. .

Abstract

Fast and widespread diagnosis is crucial to fighting against the outbreak of COVID-19. This work surveys the landscape of available and emerging biosensor technologies for COVID-19 testing. Molecular diagnostic assays based on quantitative reverse transcription polymerase chain reaction are used in most clinical laboratories. However, the COVID-19 pandemic has overwhelmed testing capacity and motivated the development of fast point-of-care tests and the adoption of isothermal DNA amplification. Antigenic and serological rapid tests based on lateral-flow immunoassays suffer from low sensitivity. Advanced digital systems enhance performance at the expense of speed and the need for large equipment. Emerging technologies, including CRISPR gene-editing tools, benefit from high sensitivity and specificity of molecular diagnostics and the easy use of lateral-flow assays. DNA sequencing and sample pooling strategies are highlighted to bring out the full capacity of the available biosensor technologies and accelerate mass testing.

Keywords: COVID-19; CRISPR diagnostics; immunoassays; isothermal amplification; molecular diagnostics.

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