Development or Disease: Caspases Balance Growth and Immunity in C. elegans

Dev Cell. 2020 May 4;53(3):259-260. doi: 10.1016/j.devcel.2020.04.006.


Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship between development and disease.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins* / genetics
  • Caspases / genetics
  • Disease*
  • p38 Mitogen-Activated Protein Kinases


  • Caenorhabditis elegans Proteins
  • p38 Mitogen-Activated Protein Kinases
  • Caspases