Development or Disease: Caspases Balance Growth and Immunity in C. elegans

Olya Yarychkivska; Shai Shaham

doi:10.1016/j.devcel.2020.04.006

Development or Disease: Caspases Balance Growth and Immunity in C. elegans

Dev Cell. 2020 May 4;53(3):259-260. doi: 10.1016/j.devcel.2020.04.006.

Authors

Olya Yarychkivska¹, Shai Shaham²

Affiliations

¹ Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
² Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: shaham@rockefeller.edu.

PMID: 32369740
DOI: 10.1016/j.devcel.2020.04.006

Abstract

Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship between development and disease.

Publication types

Comment

MeSH terms

Animals
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins* / genetics
Caspases / genetics
Disease*
p38 Mitogen-Activated Protein Kinases

Substances

Caenorhabditis elegans Proteins
p38 Mitogen-Activated Protein Kinases
Caspases

Grant support

R35 NS105094/NS/NINDS NIH HHS/United States