Keywords: CSTB, cathepsin B; CTSB+/+, wild-type; CTSB−/−, cathepsin B deficiency; CTSs, cathepsins; FABP4, fatty acid binding protein 4; FPC, fructose-palmitate-cholesterol; LDL, low density lipoprotein; MMP, metalloproteinase; NAFLD, Non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; Scad, short-chain acyl dehydrogenase-1.