The eastern Tibetan Plateau (TP) is a climatically sensitive area affected by the Indian Summer Monsoon (ISM). A new pollen record from a lacustrine sediment in Mao County shows that the study area was covered mainly by shrubs and herbs during the last deglaciation, indicating open and sparse forest grasslands. Hydrophilous herbs were mainly dominated by Cyperaceae, Poaceae, Myriophyllum, Polygonum and Typha, and they gradually increased from 18.7 to 16.8 ka, suggesting a transition to a more humid climate. This corresponds to climate cooling over the same period. From 16.8 to 14.6 ka, hydrophilous herbs continued to increase, coincident with a general ameliorating trend indicated by δ18O records from East Asia. Between 14.6 and 14.0 ka, the mean content of hydrophilous herbs reached peak in the sequence, corresponding to relatively high δ18O values during this period. From ~14.0 to 12.9 ka, the abundance of hydrophilous herbs decreased significantly. Over the same period, the Greenland ice core shows a decrease in δ18O and low-latitude cave stalagmites in China record an increase in δ18O. This implies that longitudinal temperature gradients increased and drove the southward retreat of the ISM, which in turn drove a continuous decrease in the abundance of hydrophilous herbs in the study area. From 12.9 to 11.6 ka, the mean content of hydrophilous herbs decreased to the lowest (8.3%) in the whole sequence, indicating a cold and dry climate in the study area. A positive shift in δ18O records during 11.6-10.6 ka was matched by a significant increase in the abundance of hydrophilous herbs in the study area, indicating a warm and humid climate trending. Hence, the ISM has had a significant impact on the climate of the eastern TP since the onset of deglaciation around ~16.8 ka.