Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series

Blood Adv. 2020 May 12;4(9):1859-1866. doi: 10.1182/bloodadvances.2019001325.


  1. Diagnostic and relapse diffuse large B-cell lymphoma (DLBCL) biopsies reveal increased mutational burden/loss of heterozygosity in HLA-A.

  2. Serially sampled tumor biopsies provide insight into therapeutic targets and evolutionary divergence in relapsed/refractory DLBCL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Immune Evasion*
  • Lymphoma, Large B-Cell, Diffuse* / genetics
  • Mutation
  • Neoplasm Recurrence, Local