Differentiation of two types of amyloid occurring in pituitary adenomas

Pathol Res Pract. 1988 Sep;183(5):552-4. doi: 10.1016/s0344-0338(88)80007-4.


Two types of amyloid can be differentiated by light microscopy, immunocytochemistry, and electron microscopy. The more frequent type (stellate/perivascular amyloid) is a secretory product of the adenoma cells whereas the second, rare type (spheroid amyloid) is formed by remnants of the cytoskeleton of necrotic adenoma cells.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma / pathology*
  • Adenoma / ultrastructure
  • Amyloid / analysis*
  • Biopsy
  • Humans
  • Immunohistochemistry
  • Microscopy, Electron
  • Pituitary Neoplasms / pathology*
  • Pituitary Neoplasms / ultrastructure


  • Amyloid