Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective

Chem Biol Interact. 2020 Jul 1;325:109125. doi: 10.1016/j.cbi.2020.109125. Epub 2020 May 4.

Abstract

The apparent predicament of the representative chemotherapy for managing respiratory distress calls for an obligatory deliberation for identifying the pharmaceuticals that effectively counter the contemporary intricacies associated with target disease. Multiple, complex regulatory pathways manifest chronic pulmonary disorders, which require chemotherapeutics that produce composite inhibitory effect. The cost effective natural product based molecules hold a high fervor to meet the prospects posed by current respiratory-distress therapy by sparing the tedious drug design and development archetypes, present a robust standing for the possible replacement of the fading practice of poly-pharmacology, and ensure the subversion of a potential disease relapse. This study summarizes the experimental evidences on natural products moieties and their components that illustrates therapeutic efficacy on respiratory disorders.

Keywords: Alkaloids; COPD; Flavonoids; Natural products; Respiratory disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Chronic Disease
  • Humans
  • Molecular Targeted Therapy / methods*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Respiratory Tract Diseases / drug therapy*
  • Respiratory Tract Diseases / immunology

Substances

  • Plant Extracts