Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view

Autoimmun Rev. 2020 Jul;19(7):102570. doi: 10.1016/j.autrev.2020.102570. Epub 2020 May 3.


Now COVID-19 is causing a severe public health emergency and the mortality is rapidly increasing all over the world. In the current pandemic era, although there have been many efforts to diagnose a number of patients with symptoms or close contacts, there is no definite guideline for the initial therapeutic approach for them and therefore, many patients have been dying due to a hyperinflammatory immunological reaction labeled as "cytokine storm". Severe patients are hospitalized and the treatment is done, though they have not been established yet. Currently, however, no treatment is provided for those who are isolated at home or shelter until they get severe symptoms, which will increase the harms to the patients. In this review, we discuss some important points dedicated to the management of patients with COVID-19, which should help reducing morbidity and mortality. In this era, we suggest 7 recommendations to rescue the patients and to reduce the morbidity and mortality due to COVID-19 based on the immunological point of view.

Keywords: COVID-19; Cytokine storm; Early treatment; Mortality.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / immunology
  • Coronavirus Infections / mortality*
  • Coronavirus Infections / therapy*
  • Cytokine Release Syndrome / virology
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Lung / physiopathology
  • Morbidity
  • Mouthwashes
  • Nasal Sprays
  • Pandemics
  • Plant Preparations / therapeutic use
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / mortality*
  • Pneumonia, Viral / therapy*
  • Povidone-Iodine / therapeutic use
  • SARS-CoV-2
  • Sambucus / chemistry
  • Smoking Cessation
  • Steroids / therapeutic use


  • Anti-Bacterial Agents
  • Mouthwashes
  • Nasal Sprays
  • Plant Preparations
  • Steroids
  • Hydroxychloroquine
  • Povidone-Iodine