Investigation of regional and temporal variations in Earth's gravitational field that are detected by the Gravity Recovery and Climate Experiment (GRACE) twin-satellites may be useful in earthquake epicentre determinations. This study focuses on monthly spherical harmonic coefficients that were extracted from GRACE observations, which were corrected for hydrological effects to determine earthquake epicentres. For the first time, we use the concept of deformation of Earth's gravity field to estimate invariant components of strain tensors. Four different earthquakes (Iran, China, Turkey, Nepal) were analysed that occurred between 2003 and 2015 and under different hydrological regimes. Wavelet analysis was explored as a means of refining and reconstructing tectonic signals forming the disturbance gravitational potential tensor in the GRACE gravity field models. Dilatation and maximum shear were extracted from these tensors and used to map earthquake epicentre locations. Both components reached their maxima during months of the earthquakes (respectively, 11.78 and 4.93, Bam earthquake; 61.36 and 169.10, Sichuan-Gansu border earthquake; 2415.80 and 627.93, Elazig earthquake; 98.71 and 157.37, Banepa earthquake). For the aforementioned earthquakes, we estimated their respective epicentres in the ranges: φ = 29°-29.5° λ = 58.5°-59°; φ = 32.5°-33° λ = 105.5°-106°; φ = 38.5°-39° λ = 39.5°-40°; and φ = 27.5°-28° λ = 85°-85.5°. Overall, these results agree well with values from other sources. The advance that is provided by our method compared to other research is the ability of determining earthquake epicentres with magnitudes ≤7.5 based upon GRACE observations. However, the approach is of limited use for very deep earthquakes.