Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials

Pediatr Infect Dis J. 2020 Jul;39(7):641-644. doi: 10.1097/INF.0000000000002629.


This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. identifiers: NCT01430689, NCT01034254 and NCT02465190.

Publication types

  • Clinical Trial, Phase III
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant Mortality*
  • Influenza Vaccines / administration & dosage*
  • Influenza, Human / prevention & control*
  • Maternal Mortality*
  • Meningococcal Infections / prevention & control*
  • Meningococcal Vaccines / administration & dosage*
  • Meta-Analysis as Topic
  • Middle Aged
  • Pregnancy
  • Pregnancy Complications, Infectious / prevention & control
  • Prospective Studies
  • Stillbirth
  • Young Adult


  • Influenza Vaccines
  • Meningococcal Vaccines

Associated data