Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of Quercus mongolica by Anti-Inflammatory Activity and 5α-Reductase Inhibition

Molecules. 2020 May 5;25(9):2154. doi: 10.3390/molecules25092154.


Quercus mongolica (QM)-a member of the Fagaceae family-has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride.

Keywords: Quercus mongolica; anti-acne vulgaris; pedunculagin.

MeSH terms

  • 5-alpha Reductase Inhibitors / pharmacology*
  • Acne Vulgaris / drug therapy
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Cholestenone 5 alpha-Reductase / metabolism
  • Down-Regulation
  • Humans
  • Interleukin-6 / metabolism
  • Interleukin-8 / metabolism
  • Lipopolysaccharides / adverse effects
  • Medicine, Traditional
  • Nitric Oxide / metabolism
  • Plant Extracts / pharmacology
  • Plant Leaves / chemistry
  • Quercus / chemistry*
  • Tannins / pharmacology*
  • omega-N-Methylarginine / metabolism


  • 5-alpha Reductase Inhibitors
  • Anti-Inflammatory Agents
  • CXCL8 protein, human
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-8
  • Lipopolysaccharides
  • Plant Extracts
  • Tannins
  • pedunculagin
  • omega-N-Methylarginine
  • Nitric Oxide
  • Cholestenone 5 alpha-Reductase