[Cannabis: Similarities and differences with tobacco]

Rev Mal Respir. 2020 Jun;37(6):479-487. doi: 10.1016/j.rmr.2020.04.002. Epub 2020 May 4.
[Article in French]

Abstract

Nicotine is the specific psychoactive substance of tobacco while tetrahydrocannabinol (THC) is the specific component of cannabis. The inhalation technique of cannabis is different from that of tobacco smoking: the volume of puffs is larger, inhalation is deeper, and pulmonary retention time is longer. Cannabis addiction is difficult to evaluate, both products often being smoked concomitantly. The principle physical side effects of cannabis affect organs and functions in a similar way to tobacco: pulmonary, cardiovascular, endocrine and stomatological. Gastrointestinal complications such as cannabinoid hyperemesis are specific to cannabis. Some psychological effects of THC may be acute (altered time and space perception, sensory disability, decreased vigilance, mood and dissociative disorders, hallucinations and delirium, impaired learning and memory, impaired cognitive and motor performance, panic attacks and anxiety) or chronic (lack of motivation, disorganisation of thoughts, increase in frequency and severity of schizophrenic crises). Cannabis can also be implicated in traffic and workplace accidents. Synthetic cannabinoids have increased psychotropic and somatic effects due to a greater affinity for brain cannabinoid receptors.

Keywords: Cannabis; Complications psychiques; Complications somatiques; Marijuana; Marijuana ;Tétrahydrocannabinol; Somatic and psychic complications; Tabagisme; Tetrahydrocannabinol; Tobacco smoking.

Publication types

  • Review

MeSH terms

  • Brain / drug effects
  • Brain / metabolism
  • Cannabinoids / pharmacology
  • Cannabis / chemistry
  • Cannabis / physiology*
  • Humans
  • Marijuana Abuse / complications
  • Marijuana Abuse / epidemiology
  • Marijuana Smoking / adverse effects
  • Marijuana Smoking / epidemiology
  • Nicotiana / chemistry
  • Nicotiana / physiology*
  • Psychotropic Drugs / pharmacology
  • Receptors, Cannabinoid / drug effects
  • Receptors, Cannabinoid / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Tobacco Smoking / adverse effects
  • Tobacco Smoking / epidemiology

Substances

  • Cannabinoids
  • Psychotropic Drugs
  • Receptors, Cannabinoid