A pharmacological dose of glucagon suppresses gastric emptying of a radiolabelled solid meal in humans

Scand J Clin Lab Invest. 1988 Dec;48(8):743-6. doi: 10.3109/00365518809088754.

Abstract

The effect of glucagon (143 nmol i.v. bolus followed by 430 nmol infused at a constant rate over 90 min) vs placebo (normal saline) on gastric emptying was examined in a blind randomized study in eight healthy males. The gastric emptying of a radiolabelled solid meal was measured with the use of a gamma camera. Glucagon elicited a pronounced delay in gastric emptying in all subjects examined--mean gastric transit time MTT90 glucagon 44.2 +/- 0.22 min vs placebo 38.6 +/- 0.74 min, p less than 0.001.

MeSH terms

  • Adult
  • Gastric Emptying / drug effects*
  • Glucagon / administration & dosage*
  • Humans
  • Male
  • Random Allocation

Substances

  • Glucagon