Abstract
To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy.
Keywords:
2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus disease; leukocytosis; lymphopenia; meta-analysis; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
MeSH terms
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Betacoronavirus / pathogenicity*
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Biomarkers / analysis
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COVID-19
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Comorbidity
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Coronavirus Infections / diagnosis*
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / pathology
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Coronavirus Infections / virology
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Hospitalization
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Humans
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Leukocyte Count
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Leukocytosis / diagnosis*
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Leukocytosis / epidemiology
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Leukocytosis / pathology
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Leukocytosis / virology
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Lymphopenia / diagnosis*
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Lymphopenia / epidemiology
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Lymphopenia / pathology
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Lymphopenia / virology
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Pandemics*
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Pneumonia, Viral / diagnosis*
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Pneumonia, Viral / epidemiology*
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Pneumonia, Viral / pathology
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Pneumonia, Viral / virology
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Predictive Value of Tests
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SARS-CoV-2
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Severity of Illness Index