Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity

Emerg Infect Dis. 2020 Aug;26(8):1839-1841. doi: 10.3201/eid2608.201160. Epub 2020 May 8.

Abstract

To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy.

Keywords: 2019 novel coronavirus disease; COVID-19; SARS-CoV-2; coronavirus disease; leukocytosis; lymphopenia; meta-analysis; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

Publication types

  • Meta-Analysis

MeSH terms

  • Betacoronavirus / pathogenicity*
  • Biomarkers / analysis
  • COVID-19
  • Comorbidity
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / pathology
  • Coronavirus Infections / virology
  • Hospitalization
  • Humans
  • Leukocyte Count
  • Leukocytosis / diagnosis*
  • Leukocytosis / epidemiology
  • Leukocytosis / pathology
  • Leukocytosis / virology
  • Lymphopenia / diagnosis*
  • Lymphopenia / epidemiology
  • Lymphopenia / pathology
  • Lymphopenia / virology
  • Pandemics*
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / virology
  • Predictive Value of Tests
  • SARS-CoV-2
  • Severity of Illness Index

Substances

  • Biomarkers