Clinical and histological characterization of vesicular COVID-19 rashes: a prospective study in a tertiary care hospital

Clin Exp Dermatol. 2020 Oct;45(7):872-875. doi: 10.1111/ced.14277. Epub 2020 Jun 22.


COVID-19 is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). Vesicular skin rashes have been reported as associated with COVID-19, but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID-19 who had vesicular lesions. Clinical characterization of skin findings was conducted by dermatologists. When possible, histological analysis and detection of SARS-CoV-2 in the content of the vesicles was performed. In total, 24 patients were included. A disseminated pattern was found in 18 patients (75%), and a localized pattern was found in 6 (25%). Median duration of the skin rash was 10 days. Of the 24 patients, 19 (79.2%) developed the skin rash after the onset of COVID-19 symptoms. Histological examination in two patients was consistent with viral infection, SARS-CoV-2 was not detected in four patients. This single-centre study shows the clinical characteristics of vesicular skin rashes in patients with COVID-19.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Blister / pathology
  • Blister / virology*
  • COVID-19 / complications*
  • Exanthema / pathology
  • Exanthema / virology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • SARS-CoV-2 / isolation & purification
  • Young Adult