HiJAKing SARS-CoV-2? The potential role of JAK inhibitors in the management of COVID-19

Sci Immunol. 2020 May 8;5(47):eabc5367. doi: 10.1126/sciimmunol.abc5367.

Abstract

JAK kinase inhibitors are being investigated as a way of managing cytokine storm in severe COVID-19 patients.

MeSH terms

  • Animals
  • Azetidines / therapeutic use
  • Betacoronavirus / physiology
  • COVID-19
  • Clinical Trials as Topic
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / immunology*
  • Humans
  • Janus Kinase Inhibitors / therapeutic use*
  • Pandemics
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / immunology*
  • SARS-CoV-2
  • Sulfonamides / therapeutic use

Substances

  • Azetidines
  • Janus Kinase Inhibitors
  • Sulfonamides
  • baricitinib

Supplementary concepts

  • COVID-19 drug treatment