First-in-human transcatheter pledget-assisted suture tricuspid annuloplasty for severe tricuspid insufficiency

Catheter Cardiovasc Interv. 2021 Jan 1;97(1):E130-E134. doi: 10.1002/ccd.28955. Epub 2020 May 8.

Abstract

Objectives: We report the first pledget-assisted suture tricuspid annuloplasty (PASTA) in a patient with torrential tricuspid regurgitation (TR).

Background: Tricuspid valve regurgitation is a common malignant disease with no commercially available transcatheter therapy. PASTA is a "percutaneous surgical" procedure using pledgeted sutures to create a double-orifice tricuspid valve.

Methods: An 83-year-old man had end-stage TR caused by a defibrillator lead. He consented to undergo PASTA on a compassionate basis. A double-orifice valve was created with pledgeted sutures from percutaneous right ventricular apical access.

Results: TR was reduced from torrential to trace. The vena contracta reduced to from 23 to 1 mm and annular area reduced from 1817 to 782 mm2 . However, the annulus dehisced and required closure with a percutaneous nitinol plug. The patient was discharged home and was alive 6 months later but with persistent symptoms.

Conclusions: The anatomy of a double-orifice valve can eliminate TR but a better solution is required to avoid excessive suture tension on annular tissue.

Keywords: percutaneous tricuspid valve repair; transcatheter electrosurgery; tricuspid valve regurgitation.

Publication types

  • Case Reports
  • Research Support, N.I.H., Intramural

MeSH terms

  • Aged, 80 and over
  • Cardiac Valve Annuloplasty* / adverse effects
  • Heart Valve Prosthesis Implantation* / adverse effects
  • Humans
  • Male
  • Mitral Valve
  • Sutures
  • Treatment Outcome
  • Tricuspid Valve / diagnostic imaging
  • Tricuspid Valve / surgery
  • Tricuspid Valve Insufficiency* / diagnostic imaging
  • Tricuspid Valve Insufficiency* / surgery