Survival outcomes of patients with high-grade and poorly differentiated thymic neuroendocrine carcinoma

Interact Cardiovasc Thorac Surg. 2020 Jul 1;31(1):98-101. doi: 10.1093/icvts/ivaa059.

Abstract

High-grade and poorly differentiated thymic neuroendocrine carcinoma is the rarest entity in thymic epithelial tumours. The aim of this study is to report survival data in a multi-institutional database in comparison to data in the literature. Retrospective chart review was performed on the basis of our multi-institutional database to identify patients undergoing the resection of poorly differentiated thymic neuroendocrine carcinoma between 1991 and 2018. Relevant factors were extracted, and survival analysis was performed using the Kaplan-Meier method. Twenty-one patients were identified. Five-year overall survival and recurrence-free survival were 64.6% and 51.8%, respectively. Twelve (57.1%) patients had recurrences. Due to the scarcity of data reported in the literature, our data may be used as a standard in high-grade and poorly differentiated thymic neuroendocrine carcinoma.

Keywords: Carcinoma; Neuroendocrine; Survival; Thymic.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Carcinoma, Neuroendocrine / diagnosis
  • Carcinoma, Neuroendocrine / mortality*
  • Databases, Factual
  • Female
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Neoplasm Staging*
  • Neoplasms, Glandular and Epithelial / diagnosis
  • Neoplasms, Glandular and Epithelial / mortality*
  • Retrospective Studies
  • Survival Rate / trends
  • Thymus Neoplasms / diagnosis
  • Thymus Neoplasms / mortality*

Supplementary concepts

  • Thymic epithelial tumor