Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome

Sleep Med Clin. 2020 Jun;15(2):277-288. doi: 10.1016/j.jsmc.2020.02.013.


This article provides an updated practical guide for the treatment of primary restless legs syndrome (RLS). Articles that appeared after the American Academy of Neurology guideline search were reviewed according to the same evidence rating schedule. We found limited evidence for nonpharmacologic treatment options. In moderate to severe primary RLS, pharmacologic options may be considered, including iron suppletion, an α2δ ligand, a dopamine agonist, a combination of an α2δ ligand and a dopamine agonist, or oxycodone/naloxone. This article includes treatment options in case of augmentation.

Keywords: Augmentation; Nonpharmacologic; Pharmacologic; Restless legs syndrome; Therapy; Treatment.

Publication types

  • Review

MeSH terms

  • Dopamine Agonists / therapeutic use*
  • Humans
  • Restless Legs Syndrome / drug therapy
  • Restless Legs Syndrome / therapy*


  • Dopamine Agonists