Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: Case report on three family members

Pancreatology. 2020 Jun;20(4):665-667. doi: 10.1016/j.pan.2020.04.021. Epub 2020 May 5.


Background/objectives: Abdominal pain is one of the known symptoms associated with coronavirus disease 2019. Little is known about the development of acute pancreatitis as a complication of severe acute respiratory syndrome coronavirus 2 infection. This case report describes the presentation of acute pancreatitis in two of three family members with severe COVID-19 infection.

Methods: Data were collected from three family members admitted with COVID-19 to the intensive care unit in March 2020. This study was reviewed and approved by the local data and ethics committee (31-1521-253).

Results: Two of the three family members were diagnosed with acute pancreatitis associated with SARS-CoV-2. Other causes of acute pancreatitis were excluded for both patients (including alcohol, biliary obstruction/gall stones, drugs, trauma, hypertriglyceridemia, hypercalcemia, and hypotension).

Conclusions: These cases highlight acute pancreatitis as a complication associated with COVID-19 and underlines the importance of measuring pancreas-specific plasma amylase in patients with COVID-19 and abdominal pain.

Keywords: Acute pancreatitis; COVID-19; SARS-CoV-2; Severe acute pancreatitis; Viral pancreatitis.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology
  • Acute Disease
  • Aged
  • Amylases / blood
  • COVID-19
  • Coronavirus Infections / blood
  • Coronavirus Infections / complications*
  • Coronavirus Infections / diagnostic imaging
  • Critical Care
  • Fatal Outcome
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatitis / blood
  • Pancreatitis / diagnostic imaging
  • Pancreatitis / etiology*
  • Pandemics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / diagnostic imaging
  • Radiography
  • Thorax / diagnostic imaging
  • Ultrasonography


  • Amylases