Purpose: Deproteinized bovine bone mineral (DBBM) is a type of bone substitute material widely used in tooth extraction sites. However, there is a lack of evidence supporting the benefit of DBBM used for postextraction socket preservation with regard to new bone formation. This meta-analysis and systematic review was conducted to explore whether site preservation (SP) using DBBM could provide benefits with regard to new bone formation compared with natural healing.
Materials and methods: Studies reporting histological results for postextraction SP with DBBM and natural healing from 2000 to 2019 were identified in three databases, and a meta-analysis was conducted.
Results: Five studies were included. The DBBM group had a significantly lower new bone percentage than the natural healing group, with a MD of -24.75 [95%CI: -39.77, -9.73] (P=0.001). The percentage of connective tissue in the extraction site was not significantly different between the two groups, with a MD of 0.60 [95%CI: -4.85, 6.05] (P=0.83).
Conclusions: SP using DBBM provided no additional benefit with regard to postextraction new bone formation in comparison with natural healing. Due to the lack of high-quality research, further large-sample studies and standard studies are needed to confirm these conclusions.
Keywords: Bio-Oss; Bio-Oss Collagen; DBBM; Meta-analysis; Socket preservation; Xenograft.
Copyright © 2020. Published by Elsevier Masson SAS.