Co-existence of multiple sclerosis and anti-NMDA receptor encephalitis: A case report and review of literature

Mult Scler Relat Disord. 2020 Jul;42:102075. doi: 10.1016/j.msard.2020.102075. Epub 2020 Apr 30.


Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a serious autoimmune disorder characterized by psychiatric symptoms, seizures and movement disorder. Predisposing factors have been reported since the time it was described, and its pathophysiology has been tried to be clarified over the years. Although overlap with other demyelinating diseases had been reported, such an association between Multiple Sclerosis (MS) anti ANTİ-NMDAR encephalitis is limited to only a few case reports. In this article, a patient diagnosed with relapsing remitting multiple sclerosis (RRMS) for ten years who then developed NMDA-R encephalitis while on disease modifying treatment will be presented and possible common pathophysiology with previously reported literature will be discussed.

Keywords: Multiple sclerosis; NMDAR encephalitis; Overlapping demyelinating syndromes.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnosis*
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / epidemiology
  • Comorbidity
  • Female
  • Humans
  • Multiple Sclerosis, Relapsing-Remitting / diagnosis*
  • Multiple Sclerosis, Relapsing-Remitting / epidemiology