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. 2020 May 5;142:109814.
doi: 10.1016/j.mehy.2020.109814. Online ahead of print.

Is Copper Beneficial for COVID-19 Patients?

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Free PMC article

Is Copper Beneficial for COVID-19 Patients?

Syamal Raha et al. Med Hypotheses. .
Free PMC article

Abstract

Copper (Cu) is an essential micronutrient for both pathogens and the hosts during viral infection. Cu is involved in the functions of critical immune cells such as T helper cells, B cells, neutrophils natural killer (NK) cells, and macrophages. These blood cells are involved in the killing of infectious microbes, in cell-mediated immunity and the production of specific antibodies against the pathogens. Cu-deficient humans show an exceptional susceptibility to infections due to the decreased number and function of these blood cells. Besides, Cu can kill several infectious viruses such as bronchitis virus, poliovirus, human immunodeficiency virus type 1(HIV-1), other enveloped or nonenveloped, single- or double-stranded DNA and RNA viruses. Moreover, Cu has the potent capacity of contact killing of several viruses, including SARS-CoV-2. Since the current outbreak of the COVID-19 continues to develop, and there is no vaccine or drugs are currently available, the critical option is now to make the immune system competent to fight against the SARS-CoV-2. Based on available data, we hypothesize that enrichment of plasma copper levels will boost both the innate and adaptive immunity in people. Moreover, owing to its potent antiviral activities, Cu may also act as a preventive and therapeutic regime against COVID-19.

Keywords: Blood cells; COVID-19; Contact killing; Copper; Coronavirus; Cu-deficiency; CuONPs; Cupric chloride; Immunity; ROS; SARS‐CoV‐2; Th1/Th2 cells; Viral infection.

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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References

    1. Linder M.C., Hazegh-Azam M. Copper biochemistry and molecular biology. Am J Clin Nutr. 1996;63:797S–811S. - PubMed
    1. Percival S.S. Copper and immunity. Am J Clin Nutr. 1998;67:1064S–1068S. - PubMed
    1. Failla M.L., Hopkins R.G. Is low copper status immunosuppressive? Nutr Rev. 1998;56:S59–S64. - PubMed
    1. Besold A.N., Culbertson E.M., Culotta V.C. The Yin and Yang of copper during infection. J Biol Inorg Chem. 2016;21:137–144. - PMC - PubMed
    1. Li C.X., Gleason J.E., Zhang S.X., Bruno V.M., Cormack B.P., Culotta V.C. Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase. Proc Natl Acad Sci U S A. 2015;112:E5336–E5342. - PMC - PubMed
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