Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces

Houwei Du; Chao Chen; Chengbin Ye; Feifei Lin; Jin Wei; Pincang Xia; Ronghua Chen; Sangru Wu; Qilin Yuan; Hongbin Chen; Yingchun Xiao; Nan Liu

doi:10.3389/fneur.2020.00293

Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces

Front Neurol. 2020 Apr 23:11:293. doi: 10.3389/fneur.2020.00293. eCollection 2020.

Authors

Houwei Du¹, Chao Chen^{1

2}, Chengbin Ye³, Feifei Lin¹, Jin Wei^{4

5}, Pincang Xia⁶, Ronghua Chen¹, Sangru Wu¹, Qilin Yuan¹, Hongbin Chen¹, Yingchun Xiao¹, Nan Liu^{1

7}

Affiliations

¹ Department of Neurology, Stroke Research Center, Fujian Medical University Union Hospital, Fuzhou, China.
² Department of Neurology, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, China.
³ Department of Radiology, The People's Hospital of Fujian Traditional Chinese Medicine University, Fuzhou, China.
⁴ Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, China.
⁵ School of Health Sciences, College of Health and Medicine, University of Tasmania, Newham, VIC, Australia.
⁶ Department of STDs and HIV/AIDS Control and Prevention, Fujian Province Center for Disease Control and Prevention, Fuzhou, China.
⁷ Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, China.

Abstract

Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypothesis that severe MCA stenosis or occlusion is associated with increased MRI-visible BG-EPVS. Methods: We retrospectively reviewed 112 patients with a steno-occlusive MCA from Fujian Medical University Union Hospital between January 2014 and December 2018. We rated BG-EPVS, white matter hyperintensities (WMH), and lacunes as markers of cerebral small vessel disease (CSVD) on magnetic resonance image (MRI). The severity of steno-occlusive MCA was assessed by computed tomography angiography (CTA) and was classified into moderate (50-69%), severe (70-99%), and occlusion (100%). We evaluated the association of steno-occlusive MCA for >10 BG-EPVS using logistic regression model adjusted for age, gender, hypertension, MR-visible WMH, and lacunes. We also compared the number of BG-EPVS between the affected side and unaffected side in patients with only unilateral steno-occlusive MCA. Results: In multivariable logistic regression analysis, age (OR = 1.07, 95%CI: 1.03-1.13, p = 0.003), hypertension (OR = 2.77, 95%CI: 1.02-7.51, p = 0.046), severe MCA stenosis (OR = 3.65, 95%CI: 1.12-11.87, p = 0.032), or occlusion (OR = 3.67, 95%CI: 1.20-11.27, p = 0.023) were significantly associated with >10 BG-EPVS. The number of BG-EPVS in the affected side was higher than the unaffected side in patients with severe MCA stenosis (12 [9-14] vs. 8 [6-11], p = 0.001) or occlusion (11 [7-14] vs. 8 [5-11], p = 0.028). Conclusions: BG-EPVS were more prevalent in patients with severe MCA atherosclerosis. Our findings suggest a biological link between severe steno-occlusive MCA and increased BG-EPVS. These results need confirmation in prospective studies.

Keywords: atherosclerosis; basal ganglia; cerebral small vessel disease; computed tomography angiography; enlarged perivascular spaces; magnetic resonance image; steno-occlusive middle cerebral artery.