Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pathway involving multivesicular body/exosome trafficking of iron out of the cell, diminishing the intracellular iron needed for ferroptosis.
Keywords: Ferroptosis; GPX4; PROMININ2; breast cancer; exosome; iron; multivesicular body; therapy.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.