Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.
Keywords: DNA damage; DNA repair; metabolism; pentose phosphate pathway; redox.
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.