A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity

Benjamin C Chandler; Corey Speers

doi:10.1080/23723556.2020.1737771

A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity

Mol Cell Oncol. 2020 Mar 19;7(3):1737771. doi: 10.1080/23723556.2020.1737771. eCollection 2020.

Authors

Benjamin C Chandler^{1

2

3}, Corey Speers^{1

2

3}

Affiliations

¹ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
² Rogel Cancer Center, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
³ Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA.

Abstract

Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechanism of impaired homologous recombination and represents a promising translational strategy.

Keywords: Breast cancer; TTK; homologous recombination; radiation sensitivity.

Grants and funding

T32 CA140044/CA/NCI NIH HHS/United States