Are Human Dendrites Different?

Trends Cogn Sci. 2020 Jun;24(6):411-412. doi: 10.1016/j.tics.2020.03.002. Epub 2020 Mar 30.


The first patch-clamp recordings from the dendrites of human neocortical neurons have recently been reported by Beaulieu-Laroche et al. and Gidon et al. These studies have shown that human dendrites are electrically excitable, exhibiting backpropagating action potentials and fast dendritic calcium spikes. This new frontier highlights the potential for interspecies differences in the biophysics of dendritic computation.

Keywords: cortex; dendrite; human; neural computation; patch clamp; pyramidal cell; rodent; synaptic integration.

Publication types

  • Comment

MeSH terms

  • Action Potentials
  • Dendrites*
  • Humans
  • Neurons
  • Patch-Clamp Techniques
  • Pyramidal Cells*