Multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation: a case report

BMC Pulm Med. 2020 May 11;20(1):135. doi: 10.1186/s12890-020-1168-0.


Background: Brain is one of the most common target organ of lung cancer metastasis, while descriptions of intraventricular carcinomatosis could hardly be found among previous cases. To date no cases from lung adenocarcinoma have been reported in the literature.

Case presentation: We report here a case of multiple intraventricular metastases from lung adenocarcinoma with EGFR G719X mutation. This 64-year-old woman was referred to our hospital with complaints of dizziness and vomiting. Target therapy with afatinib was initiated and the lesions in both lung and brain achieved good partial responses.

Conclusions: This case report revealed a phenomenon of rare intraventricular metastasis from lung cancer, which should be carefully distinguished from primary ventricular tumors. Compared to brain parenchyma metastasis, intraventricular lesions would cause more severe symptoms which may be rapidly progressive. Target therapy could become a potential option in such patients with non-drugresistant EGFR mutations.

Keywords: Case report; Intraventricular metastases; Lung adenocarcinoma; Tyrosine kinase inhibitor.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma of Lung / diagnostic imaging
  • Adenocarcinoma of Lung / drug therapy
  • Adenocarcinoma of Lung / genetics
  • Adenocarcinoma of Lung / pathology*
  • Afatinib
  • Antineoplastic Agents / therapeutic use*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / secondary*
  • ErbB Receptors / genetics
  • Exons / drug effects
  • Fatal Outcome
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Mutation
  • Tomography, X-Ray Computed


  • Antineoplastic Agents
  • Afatinib
  • EGFR protein, human
  • ErbB Receptors