Peptide bond cleavage in the presence of Ni-containing particles

Metallomics. 2020 May 27;12(5):649-653. doi: 10.1039/d0mt00070a.


NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their molar equivalent of soluble Ni(ii) salt. These findings highlight the efficacy of delivery of toxic Ni2+ by these environmentally available particles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydrolysis
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Nickel / chemistry*
  • Peptide Fragments / chemistry*
  • Peptide Fragments / metabolism*


  • Peptide Fragments
  • Nickel