Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features

Breast Cancer Res Treat. 2020 Jul;182(1):169-179. doi: 10.1007/s10549-020-05651-0. Epub 2020 May 11.

Abstract

Background: Matrix metalloproteinases (MMP)-2 and -9 may play an important role in adipogenesis and carcinogenesis. We investigated whether some polymorphisms located in these genes are associated with body adiposity and mammographic breast density, which are risk factors for breast cancer.

Methods: Our study population included 731 premenopausal women. Multivariate generalized linear models were used to evaluate the association of polymorphisms rs243865 in MMP-2 and rs3918242, rs17576, rs2250889 and rs2274756 in MMP-9 with anthropometric factors that refer to adiposity and mammographic features (percent density, dense area and non-dense area) measured by computer-assisted method.

Results: The number of copies of rs243865 T allele in MMP-2 was associated with increased means of anthropometric factors (ptrend < 0.05 for all except waist-to-hip ratio). The same allele of rs243865 was associated with decreased mean percent density (ptrend = 0.036) and increased mean non-dense area (ptrend = 0.031) when adjusted for potential confounders, but these associations were attenuated when further adjusted for adiposity.

Conclusion: These findings suggest that the relation between rs243865 in MMP-2 and mammographic features could be mediated by adiposity.

Keywords: Adiposity; Breast density; Mammographic features; Matrix metalloproteinases; Polymorphisms.

MeSH terms

  • Adiposity / genetics*
  • Body Mass Index
  • Breast Density / genetics*
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Canada / epidemiology
  • Female
  • Follow-Up Studies
  • Humans
  • Mammography / methods*
  • Matrix Metalloproteinase 2 / genetics*
  • Matrix Metalloproteinase 9 / genetics*
  • Middle Aged
  • Polymorphism, Genetic*
  • Risk Factors
  • Waist-Hip Ratio

Substances

  • MMP2 protein, human
  • Matrix Metalloproteinase 2
  • MMP9 protein, human
  • Matrix Metalloproteinase 9