25-Hydroxyvitamin D Concentrations Are Lower in Patients With Positive PCR for SARS-CoV-2

Nutrients. 2020 May 9;12(5):1359. doi: 10.3390/nu12051359.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation.

Keywords: COVID-19; SARS-CoV-2; concentrations; coronavirus; deficiency; vitamin D.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Betacoronavirus / isolation & purification
  • Coronavirus Infections / blood*
  • Coronavirus Infections / diagnosis
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral / blood*
  • Pneumonia, Viral / diagnosis
  • Polymerase Chain Reaction
  • Retrospective Studies
  • Switzerland
  • Vitamin D / administration & dosage
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • Vitamin D
  • 25-hydroxyvitamin D

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2