Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May 12;14(1):17.
doi: 10.1186/s40246-020-00267-3.

COVID-19 Vulnerability: The Potential Impact of Genetic Susceptibility and Airborne Transmission

Affiliations
Free PMC article
Review

COVID-19 Vulnerability: The Potential Impact of Genetic Susceptibility and Airborne Transmission

Krystal J Godri Pollitt et al. Hum Genomics. .
Free PMC article

Abstract

The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of COVID-19 cases now exceeding 2 million worldwide, it is apparent that (i) transmission of SARS-CoV-2 is very high and (ii) there are large variations in disease severity, one component of which may be genetic variability in the response to the virus. Controlling current rates of infection and combating future waves require a better understanding of the routes of exposure to SARS-CoV-2 and the underlying genomic susceptibility to this disease. In this mini-review, we highlight possible genetic determinants of COVID-19 and the contribution of aerosol exposure as a potentially important transmission route of SARS-CoV-2.

Conflict of interest statement

Not applicable

Similar articles

See all similar articles

References

    1. Zhou F, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan China: a retrospective cohort study. Lancet. 2020;395:1054–1062. doi: 10.1016/S0140-6736(20)30566-3. - DOI - PubMed
    1. Cao Y, et al. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov. 2020;6:11. doi: 10.1038/s41421-020-0147-1. - DOI - PMC - PubMed
    1. Hussain M, et al. Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein. J Med Virol. 2020. 10.1002/jmv.25832. - PMC - PubMed
    1. Walls AC, et al. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell. 2020. 10.1016/j.cell.2020.02.058. - PMC - PubMed
    1. Hoffmann M, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020. 10.1016/j.cell.2020.02.052. - PMC - PubMed

MeSH terms

Supplementary concepts

Feedback