Molecular cross talk among the components of the regulatory machinery of mitochondrial structure and quality control

Exp Mol Med. 2020 May;52(5):730-737. doi: 10.1038/s12276-020-0434-9. Epub 2020 May 12.

Abstract

Mitochondrial dysfunction critically impairs cellular health and often causes or affects the progression of several diseases, including neurodegenerative diseases and cancer. Thus, cells must have several ways to monitor the condition of mitochondrial quality and maintain mitochondrial health. Accumulating evidence suggests that the molecular machinery responding to spontaneous changes in mitochondrial morphology is associated with the routine mitochondrial quality control system. In this short review, we discuss recent progress made in linking mitochondrial structural dynamics and the quality control system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Susceptibility
  • Energy Metabolism
  • Humans
  • Mitochondria / physiology*
  • Mitochondria / ultrastructure
  • Mitochondrial Dynamics*
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism
  • Organ Specificity

Substances

  • Mitochondrial Proteins