Recent advances in understanding the development and function of γδ T cells

F1000Res. 2020 Apr 29;9:F1000 Faculty Rev-306. doi: 10.12688/f1000research.22161.1. eCollection 2020.


γδ T cells are a subset of T cells with attributes of both the innate and adaptive arms of the immune system. These cells have long been an enigmatic and poorly understood component of the immune system and many have viewed them as having limited importance in host defense. This perspective persisted for some time both because of critical gaps in knowledge regarding how the development of γδ T cells is regulated and because of the lack of effective and sophisticated approaches through which the function of γδ T cells can be manipulated. Here, we discuss the recent advances in both of these areas, which have brought the importance of γδ T cells in both productive and pathologic immune function more sharply into focus.

Keywords: development; function; immune response; γδ T cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Lymphocytes*


  • Receptors, Antigen, T-Cell, gamma-delta