Curcumin for the Management of Periodontal Diseases: A Review

Curr Pharm Des. 2020;26(34):4277-4284. doi: 10.2174/1381612826666200513112607.


Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receiving attention for the management of periodontitis owing to their general safety and efficacy. Curcumin, a bioactive polyphenol extracted from Curcuma longa, has been shown to possess antioxidant, antimicrobial, anti-inflammatory and analgesic properties. Several studies have assessed the efficacy of curcumin against periodontal diseases. These studies have shown equivalent or even higher efficacy of curcumin compared to the commonly used medications for the management of periodontitis such as chlorhexidine. Herein, we review the experimental and clinical findings on the anti-periodontitis effects of curcumin and the pharmacological mechanisms underlying these effects.

Keywords: Inflammation; curcumin; gingivitis; herbal medicine; herbal mouthwash; periodontitis.

Publication types

  • Review

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Chlorhexidine / therapeutic use
  • Curcumin* / therapeutic use
  • Humans
  • Inflammation / drug therapy
  • Periodontal Diseases* / drug therapy
  • Periodontitis* / drug therapy


  • Anti-Inflammatory Agents
  • Curcumin
  • Chlorhexidine