PD-L1 and PD-L2 Mutations in Pediatric Hodgkin Lymphoma: Do They Have Any Prognostic Significance?

Fetal Pediatr Pathol. 2022 Feb;41(1):49-57. doi: 10.1080/15513815.2020.1764680. Epub 2020 May 13.

Abstract

Background: Reed-Sternberg cells can escape from the immune system by enhancement of the expression of PD-L1 and PD-L2. Objectives: The aim of the present study was to investigate the significance PD-L1 and PD-L2 gene mutations in childhood Hodgkin Lymphoma's (HL). Methods: The study included 39 pediatric classical HL cases. PD-L1 and PD-L2 mutations were determined by Sanger sequencing. Clinicopathological parameters were obtained from patients' records. Results: Eight cases (20.5%) showed p.R260C mutations, and three (7.7%) p.R234L in the exome 5 of PD-L1 gene. None of the cases had PD-L2 mutations. p.R260C mutation exhibited a significant relationship with older age and nodular sclerosing (NS) histology and was associated with longer event free survival. Conclusions: Although PD-L1 mutational status did not show statistically significance with well-established prognostic factors, our preliminary data indicate that p.R260C mutation of PD-L1 gene may be associated with longer event free survival in older patients and NS histology in pediatric HL.

Keywords: Hodgkin lymphoma; PD-L1; PD-L2.

MeSH terms

  • Aged
  • B7-H1 Antigen* / genetics
  • Child
  • Hodgkin Disease* / genetics
  • Humans
  • Mutation
  • Prognosis
  • Programmed Cell Death 1 Ligand 2 Protein / genetics*

Substances

  • B7-H1 Antigen
  • PDCD1LG2 protein, human
  • Programmed Cell Death 1 Ligand 2 Protein