Cancer Genetics

Surg Clin North Am. 2020 Jun;100(3):483-498. doi: 10.1016/j.suc.2020.02.012. Epub 2020 Apr 16.


For most individuals, cancer development is multifactorial; however, up to 10% of all cancers are related to an inherited genetic mutation. As health care shifts to having a greater emphasis on prevention, care providers, including general surgeons, will need to play a role in identifying patients at high risk for cancer development. Genetic testing provides a tool to determine those patients with a genetic mutation and to whom appropriate preventive care and treatment may be offered. It is imperative for general surgeons to understand the role genetics plays in the care of individual patients and their relatives.

Keywords: BRCA; Familial adenomatous polyposis; Genetic testing; Hereditary cancer syndromes; Lynch syndrome.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli / diagnosis
  • Adenomatous Polyposis Coli / genetics
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics
  • Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • DNA Mutational Analysis
  • Female
  • Genetic Counseling
  • Genetic Testing
  • Humans
  • Male
  • Neoplasms / diagnosis
  • Neoplasms / genetics*
  • Neoplastic Syndromes, Hereditary / diagnosis
  • Neoplastic Syndromes, Hereditary / genetics
  • Ovarian Neoplasms / diagnosis
  • Ovarian Neoplasms / genetics
  • Pedigree
  • Preconception Care
  • Risk Assessment
  • Stomach Neoplasms / genetics