The association between midlife lipid levels and late-life brain amyloid deposition

Neurobiol Aging. 2020 Aug;92:73-74. doi: 10.1016/j.neurobiolaging.2020.03.015. Epub 2020 Apr 15.


Elevated low-density lipoprotein cholesterol and total cholesterol in midlife and decline in total cholesterol from mid- to late-life are associated with incident dementia. Whether brain amyloid deposition mediates this relationship is unclear. We explored the association between midlife blood lipid levels and mid- to late-life change in lipid levels with brain amyloid deposition assessed using florbetapir PET scans in a biracial sample of 325 nondemented participants of the Atherosclerosis Risk in Communities-PET Amyloid Imaging study. Midlife total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides were not significantly associated with late-life amyloid burden after adjusting for covariates. Associations between changes in lipids and late-life amyloid deposition were similarly null. Lipids may contribute to dementia risk through alternate mechanisms.

Keywords: Alzheimer’s disease; Amyloid; Epidemiology; Lipids.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amyloidogenic Proteins / metabolism*
  • Brain / diagnostic imaging
  • Brain / metabolism*
  • Cholesterol / blood*
  • Cholesterol, HDL / blood*
  • Cholesterol, LDL / blood*
  • Dementia / etiology*
  • Female
  • Humans
  • Male
  • Negative Results*
  • Positron-Emission Tomography
  • Triglycerides / blood*


  • Amyloidogenic Proteins
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Triglycerides
  • Cholesterol