Antimicrobial Resistance in ESKAPE Pathogens

Clin Microbiol Rev. 2020 May 13;33(3):e00181-19. doi: 10.1128/CMR.00181-19. Print 2020 Jun 17.


Antimicrobial-resistant ESKAPE ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial resistance surveillance. This looming health threat has restimulated interest in the development of new antimicrobial therapies, has demanded the need for better patient care, and has facilitated heightened governance over stewardship practices.

Keywords: Acinetobacter; Enterobacter; Enterobacterales; Enterococcus; Klebsiella; Pseudomonas aeruginosa; Staphylococcus aureus; antibiotic resistance; multidrug resistance.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects*
  • Bacteria / genetics*
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Drug Discovery*
  • Drug Resistance, Multiple, Bacterial*
  • Humans


  • Anti-Bacterial Agents