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Case Reports
. 2020 May 13;508:98-102.
doi: 10.1016/j.cca.2020.04.034. Online ahead of print.

Dynamic Changes in Routine Blood Parameters of a Severe COVID-19 Case

Free PMC article
Case Reports

Dynamic Changes in Routine Blood Parameters of a Severe COVID-19 Case

Guoguang Lu et al. Clin Chim Acta. .
Free PMC article


Background: Novel coronavirus infectious disease (COVID-19) has been spreading worldwide, and tracking laboratory indexes during the diagnosis and treatment of patients with severe COVID-19 can provide a reference for patients in other countries and regions.

Methods: We closely tracked the epidemiological history, diagnosis and treatment process, as well as dynamic changes in routine blood indicators, of a severe COVID-19 patient who was hospitalized for 26 days.

Results: Our study found that the patient's condition worsened in the first week after admission, white blood cells (WBCs), neutrophils, lymphocytes, monocytes, eosinophils, red blood cells (RBCs), hemoglobin, neutrophil lymphocyte ratio (NLR), platelets (PLT) and platelet lymphocyte ratio (PLR) decreased. On the 7th day of admission, the levels of these cells decreased to their lowest values, though the red blood cell distribution width (RDW) and C-reactive protein (CRP) level remained at high values. From 8 to 14 days of admission, the patient's condition improved, hypoxemia was corrected, and mechanical ventilation was discontinued. The number of WBCs, neutrophils, monocytes, eosinophils and lymphocytes increased gradually, and the erythrocyte parameters stopped declining and stabilized in a certain range; CRP decreased rapidly. On the 20th day of admission, the nucleic acid test was negative, WBC, neutrophil, CRP, NLR and PLR decreased gradually, and monocyte, lymphocyte, and eosinophil counts increased. Although RBCs and hemoglobin (Hb) levels continued to decrease, RDW gradually increased, indicating the recovery of hematopoiesis. In addition, it should be noted that monocytes and eosinophils were at extremely low levels within 10 days after admission; the recovery time of eosinophils was approximately 12 days after admission, which was earlier than other parameters, which might be of great value in judging the progress of the disease.

Conclusions: Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect.

Keywords: COVID-19; Dynamic; Routine blood parameters.


Fig. 1
Fig. 1
Disease progression and medical intervention of the patient.
Fig. 2
Fig. 2
Dynamic changes in WBC and CRP in the patient during hospitalization.
Fig. 3
Fig. 3
Dynamic changes in erythrocyte parameters, PLT, NLR and PLR in the patient during hospitalization.

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