A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Cell. 2020 Jun 11;181(6):1194-1199. doi: 10.1016/j.cell.2020.05.016. Epub 2020 May 13.

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Betacoronavirus / physiology
  • COVID-19
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / genetics*
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / physiopathology
  • Disease Resistance
  • Genetic Association Studies
  • Genetic Diseases, Inborn / immunology
  • Genetic Predisposition to Disease*
  • Genetic Variation
  • Genome, Human
  • Host-Pathogen Interactions
  • Humans
  • Infections / genetics
  • Infections / immunology
  • Infections / physiopathology
  • Pandemics
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / genetics*
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / physiopathology
  • SARS-CoV-2