A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova; Helen C Su; COVID Human Genetic Effort

doi:10.1016/j.cell.2020.05.016

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Cell. 2020 Jun 11;181(6):1194-1199. doi: 10.1016/j.cell.2020.05.016. Epub 2020 May 13.

Authors

Jean-Laurent Casanova¹, Helen C Su²; COVID Human Genetic Effort

Collaborators

COVID Human Genetic Effort:
Laurent Abel, Alessandro Aiuti, Saleh Almuhsen, Andres Augusto Arias, Paul Bastard, Catherine Biggs, Dusan Bogunovic, Bertrand Boisson, Stephanie Boisson-Dupuis, Alexandre Bolze, Anastasia Bondarenko, Aziz Bousfiha, Petter Brodin, Jacinta Bustamante, Manish Butte, Giorgio Casari, Michael Ciancanelli, Aurelie Cobat, Antonio Condino-Neto, Megan Cooper, Clifton Dalgard, Sara Espinosa, Hagit Feldman, Jacques Fellay, Jose Luis Franco, David Hagin, Yuval Itan, Emmanuelle Jouanguy, Carrie Lucas, Davood Mansouri, Isabelle Meyts, Joshua Milner, Trine Mogensen, Tomohiro Morio, Lisa Ng, Luigi D Notarangelo, Satoshi Okada, Tayfun Ozcelik, Pere Soler Palacín, Anna Planas, Carolina Prando, Anne Puel, Aurora Pujol, Claire Redin, Laurent Renia, Jose Carlos Rodriguez Gallego, Lluis Quintana-Murci, Vanessa Sancho-Shimizu, Vijay Sankaran, Mikko R J Seppänen, Mohammad Shahrooei, Andrew Snow, András Spaan, Stuart Tangye, Jordi Perez Tur, Stuart Turvey, Donald C Vinh, Horst von Bernuth, Xiaochuan Wang, Pawel Zawadzki, Qian Zhang, Shenying Zhang

Affiliations

¹ St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller Unversity, New York, NY, USA; Howard Hughes Medical Institute, New York, NY, USA; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France. Electronic address: casanova@rockefeller.edu.
² Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Abstract

SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers-individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease-present a unique opportunity to reveal human genetic determinants of infection and disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Betacoronavirus / physiology
COVID-19
Coronavirus Infections / epidemiology
Coronavirus Infections / genetics*
Coronavirus Infections / immunology*
Coronavirus Infections / physiopathology
Disease Resistance
Genetic Association Studies
Genetic Diseases, Inborn / immunology
Genetic Predisposition to Disease*
Genetic Variation
Genome, Human
Host-Pathogen Interactions
Humans
Infections / genetics
Infections / immunology
Infections / physiopathology
Pandemics
Pneumonia, Viral / epidemiology
Pneumonia, Viral / genetics*
Pneumonia, Viral / immunology*
Pneumonia, Viral / physiopathology
SARS-CoV-2

Abstract

Publication types

MeSH terms

Grants and funding