Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19

Clin Immunol. 2020 Jul;216:108464. doi: 10.1016/j.clim.2020.108464. Epub 2020 May 13.
No abstract available

Publication types

  • Letter

MeSH terms

  • Betacoronavirus / drug effects
  • Betacoronavirus / immunology
  • Betacoronavirus / pathogenicity
  • COVID-19
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / immunology
  • Coronavirus Infections / virology
  • Cytokine Release Syndrome / etiology
  • Cytokine Release Syndrome / immunology
  • Cytokine Release Syndrome / pathology
  • Cytokine Release Syndrome / prevention & control*
  • Cytokines / antagonists & inhibitors*
  • Cytokines / genetics
  • Cytokines / immunology
  • Disease Progression
  • Gene Expression Regulation
  • Humans
  • Immunity, Innate / drug effects
  • Immunologic Factors / therapeutic use*
  • Molecular Targeted Therapy / methods
  • Pandemics*
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / virology
  • SARS-CoV-2
  • Sirolimus / therapeutic use*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • T-Lymphocytes / virology

Substances

  • Cytokines
  • Immunologic Factors
  • Sirolimus