The combination of N-Acetyl-L-Cysteine, Pelargonium sidoides and Justicia adhatoda (NAXX) exerts bacteriostatic activity against S. aureus and E. coli

Nat Prod Res. 2021 Dec;35(23):5360-5363. doi: 10.1080/14786419.2020.1761359. Epub 2020 May 14.

Abstract

Many herbal agents and medicinal plants have provided clinical interest due to their therapeutic properties, availability and lower side effects. The aim of this study was to understand the anti-bacterial activity of the combination of Pelargonium sidoides (PEL), Justicia adhatoda (ADH) and N-Acetyl-L-Cysteine (NAC) (NAXX). We found that NAXX had strong and long-term bacteriostatic activity, which was related to its anti-oxidant activity. Our data demonstrate that NAXX is an innovative medicinal plant-derived strategy to manage of oxidative stress- and microbial-based diseases.

Keywords: Justicia adhatoda; N-Acetyl-L-Cysteine; Pelargonium sidoides; anti-microbial activity; anti-oxidant.

MeSH terms

  • Acetylcysteine / pharmacology
  • Escherichia coli
  • Justicia*
  • Methicillin-Resistant Staphylococcus aureus*
  • Pelargonium*
  • Plant Extracts / pharmacology
  • Staphylococcus aureus

Substances

  • Plant Extracts
  • Acetylcysteine